Hepatitis C virus infection protein network

نویسندگان

  • B de Chassey
  • V Navratil
  • L Tafforeau
  • M S Hiet
  • A Aublin-Gex
  • S Agaugué
  • G Meiffren
  • F Pradezynski
  • B F Faria
  • T Chantier
  • M Le Breton
  • J Pellet
  • N Davoust
  • P E Mangeot
  • A Chaboud
  • F Penin
  • Y Jacob
  • P O Vidalain
  • M Vidal
  • P André
  • C Rabourdin-Combe
  • V Lotteau
چکیده

A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein-protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFbeta pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.

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عنوان ژورنال:
  • Molecular Systems Biology

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2008